Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.

Raquel Sánchez-VaroAlexander López-SalasRasiel Beltran-CasanuevaEstela Díaz-SánchezJose Erik Alvarez-ContinoMiguel Angel Barbancho-FernándezPedro Serrano-CastroKjell FuxeDasiel O Borroto-EscuelaNatalia García-CasaresManuel Narváez

Published in: Behavioral and brain functions : BBF (2024)

Our results show that intranasal co-delivery of GALR2 and NPY1R agonists improves spatial memory, boosts neuronal survival, and influences neuronal differentiation in adult rats. The significant role of GALR2 is emphasized, suggesting new potential therapeutic strategies for cognitive decline.

Keyphrases

cognitive decline
mild cognitive impairment
cerebral ischemia
human health
working memory
binding protein
subarachnoid hemorrhage
climate change