Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition.

Jan HansenJacob JohnsenJan Møller NielsenCharlotte Brandt Sørensen Casper Carlsen Elkjær Nichlas Riise Jespersen Hans Erik Botker

Published in: Drug design, development and therapy (2020)

The cardioprotective efficacy of XE991 seems to depend on its presence during ischemia and early reperfusion and do not rely on RISK (p-Akt and p-Erk) and SAFE (p-STAT3) pathway activation. The protective effect of XE991 seems mainly mediated through the Kv7.4 subchannel.

Keyphrases

cell proliferation
signaling pathway
image quality
dual energy
acute myocardial infarction
pi k akt
computed tomography
heart failure
coronary artery disease