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A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance.

Hyeong-Min LeeM Bram KuijerNerea Ruiz BlanesEllen P ClarkMegumi AitaLorena Galiano ArjonaAgnieszka KokotNoah SciakyJeremy M SimonSanchita BhatnagarBenjamin D PhilpotAndrea Cerase
Published in: Journal of neurodevelopmental disorders (2020)
Our results suggest that inhibition of the JAK/STAT pathway is a new potential pathway to reinstate MeCP2 gene expression as an efficient RTT treatment.
Keyphrases
  • small molecule
  • gene expression
  • protein protein
  • dna methylation
  • high throughput
  • risk assessment
  • combination therapy