Evaluation of weight change and hypoglycaemia as mediators in the association between insulin use and death.
Jea Young MinAmber J HackstadtMarie R GriffinRobert A GreevyJonathan ChipmanCarlos G GrijalvaAdriana M HungChristianne L RoumiePublished in: Diabetes, obesity & metabolism (2019)
We observed an increased risk of death among metformin users intensifying treatment with insulin versus sulphonylurea and surviving 6 months of intensified therapy, but not among those surviving 12 months. This association was mediated in part by weight change.