Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population.
Mariana Bonjiorno MartinsFernando de Assis BatistaNatassia Elena BufaloKarina Colombera PeresMurilo MeneghettiLigia Vera Montali da AssumpçãoLaura Sterian WardPublished in: Endocrine (2020)
These findings indicate that although genetic variants in IL-4 and IL-4R do not influence the risk or outcome of DTC patients, their influence on the behavior of thyroid tumors deserves further investigation.