Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains.

Julio BarreraLingyun SongJulia E GamacheMelanie E GarrettAlexias SafiYoung YunIvana PremasingheDaniel SpragueDanielle ChipmanJeffrey LiHélène FradinKaren SoldanoRaluca GordânAllison E Ashley-KochGregory E CrawfordOrnit Chiba-Falek

Published in: Molecular neurodegeneration (2021)

Using brain sorted-nuclei enabled the identification of sex-dependent cell type-specific LOAD alterations in chromatin structure. These findings enhance the interpretation of LOAD-GWAS discoveries, provide potential pathomechanisms, and suggest novel LOAD-loci.

Keyphrases

late onset
genome wide
early onset
gene expression
dna damage
transcription factor
dna methylation
white matter
genome wide association study
cognitive decline
resting state
neuropathic pain
spinal cord
multiple sclerosis
oxidative stress
brain injury
subarachnoid hemorrhage
genome wide association