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Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes.

Felix C VauraHyunkyung KimMiriam S Udlernull nullVeikko V SalomaaLeo LahtiTeemu J Niiranen
Published in: Circulation. Genomic and precision medicine (2022)
Our unsupervised analysis demonstrates that the genetic basis of hypertension can be understood as a mixture of 4 broad, clinically interpretable components capturing disease heterogeneity. These components could be used to stratify individuals into specific genetic subtypes and, therefore, to benefit personalized health care and pharmaceutical research.
Keyphrases
  • blood pressure
  • genome wide
  • healthcare
  • machine learning
  • copy number
  • single cell
  • dna methylation
  • gene expression
  • arterial hypertension
  • health insurance