Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes.
Felix C VauraHyunkyung KimMiriam S Udlernull nullVeikko V SalomaaLeo LahtiTeemu J NiiranenPublished in: Circulation. Genomic and precision medicine (2022)
Our unsupervised analysis demonstrates that the genetic basis of hypertension can be understood as a mixture of 4 broad, clinically interpretable components capturing disease heterogeneity. These components could be used to stratify individuals into specific genetic subtypes and, therefore, to benefit personalized health care and pharmaceutical research.