A Bivalent Recombinant Mycobacterium bovis BCG Expressing the S1 Subunit of the Pertussis Toxin Induces a Polyfunctional CD4+ T Cell Immune Response.

Alex Issamu KannoCibelly GoulartLuciana Cezar de Cerqueira LeiteAna C PagliaroneIvan Pereira Nascimento

Published in: BioMed research international (2019)

rBCG-S1+S1i was able to express the two forms of S1PT and elicited higher induction of polyfunctional CD4+ T cells, indicating enhanced immunogenicity and suggesting its use as immunotherapy for bladder cancer.

Keyphrases

immune response
escherichia coli
mycobacterium tuberculosis
dendritic cells
toll like receptor
cell free