Genomic Evolutionary Patterns of Leiomyosarcoma and Liposarcoma.
Ali Amin-MansourSuzanne GeorgeStefano SioleticScott L CarterMara W RosenbergAmaro Taylor-WeinerChip StewartAaron ChevalierSara SeepoAdam TracyGad A GetzJason L HornickMarisa R NucciBradley QuadeGeorge D DemetriChandrajit P RautLevi A GarrawayEliezer M Van AllenAndrew J WagnerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
From a genomic perspective, leiomyosarcoma metastases contain genetic alterations that are also found in primary tumors. WDLPS and DDLPS, however, appear to divergently evolve from a common precursor harboring 12q amplification, rather than as a transformation to a higher-grade tumor. Further efforts to identify specific drivers of these distinct evolutionary patterns may inform future translational and clinical research in STS.