Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy.

Carsten KriegLukas M WeberBruno FossoMarinella MarzanoGary HardimanMonica M OlcinaEnric DomingoSahar El AidyKhalil MallahMark D RobinsonSilvia Guglietta

Published in: Journal for immunotherapy of cancer (2022)

Our findings reveal that C3aR may act as a previously unrecognized checkpoint to enhance antitumor immunity in CRC. C3aR can thus be exploited to overcome ICB resistance in a larger group of patients with CRC.

Keyphrases

dna damage
cell cycle
cell proliferation
oxidative stress
signaling pathway
genome wide
single cell