Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity.
Nancy R GrahamAnnalis N WhitakerCamilla A StrotherAshley K MilesDore GrierBenjamin D McElvanyEmily A BruceMatthew E PoynterKristen K PierceBeth D KirkpatrickRenee D StapletonGary C AnEline van den Broek-AltenburgJason W BottenJessica W CrothersSean A DiehlPublished in: Clinical & translational immunology (2020)
Our results suggest that anti-RBD-S IgG reflect functional immune responses to SARS-CoV-2, but do not completely explain age- and sex-related disparities in COVID-19 fatalities.