Elevated cerebrospinal fluid homocysteine is associated with blood-brain barrier disruption in amyotrophic lateral sclerosis patients.

Yonghua WuXu YangXiaogang LiHaining WangTiancheng Wang

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)

BBB permeability is increased in ALS patients. CSF Hcy level is associated with BBB integrity. Qalb is a significantly independent predisposing factor for CSF Hcy.

Keyphrases

blood brain barrier
end stage renal disease
ejection fraction
cerebrospinal fluid
newly diagnosed
chronic kidney disease
endothelial cells
patient reported