Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity.

Jamila LaoukiliAlexander ConstantinidesEmma C E WassenaarSjoerd G EliasDanielle A E RaatsSusanne J van SchelvenJonathan van WettumRichard VolckmannJan KosterAlwin D R HuitemaSimon W NienhuijsIgnace H J T de HinghRené J WiezerHelma M U van GrevensteinInne H M Borel RinkesDjamila BoermaOnno W Kranenburg

Published in: British journal of cancer (2022)

These results link oxaliplatin resistance of colorectal PM to their CMS4 status and high reducing capacity. Inhibiting the reducing capacity of PM may be an effective strategy to overcome PM resistance to oxaliplatin.

Keyphrases

particulate matter
air pollution
polycyclic aromatic hydrocarbons
heavy metals
signaling pathway
water soluble
risk assessment
single molecule