NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth.
Chufan CaiJiayi TuJeronimo NajarroRukang ZhangYuming GuoFreya Q ZhangJiacheng LiZhicheng XieRui SuLei DongNicole S ArellanoMichele CiboddoShannon E ElfXue GaoJing ChenRong WuPublished in: Molecular cancer research : MCR (2024)
Our findings suggest that targeting the AHCYL1-IP3R axis presents a novel therapeutic approach for NRAS-mutated melanomas, with potential applicability to all cancers harboring RAS mutations, such as KRAS-mutated human colorectal cancers.