The piperazine scaffold for novel drug discovery efforts: the evidence to date.

Maria Novella Romanelli Dina Manetti Laura Braconi Silvia DeiAlessio GabelliniElisabetta Teodori

Published in: Expert opinion on drug discovery (2022)

Piperazine is widely used due to its peculiar characteristics, such as solubility, basicity, chemical reactivity, and conformational properties. This moiety has represented an important tool to modulate pharmacokinetic and pharmacodynamic properties of drugs.

Keyphrases

drug discovery
molecular dynamics
molecular dynamics simulations
single molecule
quality improvement
tissue engineering
drug induced