Examining the biological pathways underlying clinical heterogeneity in Sjogren's syndrome: proteomic and network analysis.
Joe Scott BerryJessica TarnJohn CasementPierre-Marie DuretLauren ScottKarl WoodSvein-Joar JohnsenGunnel NordmarkValérie Devauchelle-PensecRaphaèle SerorBenjamin A FisherFransesca BaroneSimon J BowmanMichele BombardieriDennis LendremRenaud FeltenJacques-Eric GottenbergWan-Fai NgPublished in: Annals of the rheumatic diseases (2023)
Our data provide clues to the pathways contributing to the glandular and non-glandular manifestations of SS and to potential therapeutic targets for different SS subtypes. In addition, our analysis highlights the need for further exploration of altered metabolism and mitochondrial dysfunction in the context of SS subtypes.