Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway.

Tomoyuki KawaguchiKoichi OkamotoShota FujimotoMasahiro BandoHironori WadaHiroshi MiyamotoYasushi SatoNaoki MugurumaKatsuhisa HorimotoTetsuji Takayama

Published in: Journal of gastroenterology (2023)

Our data strongly suggest that lansoprazole is the most effective chemopreventive agent against SSL, and that lansoprazole induces G1 cell cycle arrest by downregulating Skp2 and upregulating p27 in SSL cells.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
cell death
induced apoptosis
cell proliferation
electronic health record
epithelial mesenchymal transition
cell cycle
big data
artificial intelligence