Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing Interruption in Patients Treated for Acute Postoperative Pain.
Sabry Salama AyadMark A DemitrackDavid A BurtCathy MichalskyLinda WaseMichael J FosslerAshish K KhannaPublished in: Clinical drug investigation (2020)
Using DI as a surrogate for OIRD indicates improved respiratory safety with oliceridine versus morphine that merits further investigation.