SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study.

Jingshu LiuJiangfeng QiuZhiqi ZhangLei ZhouYunzhe LiDongyan DingYang ZhangDongling ZouDong WangQi ZhouTingyuan Lang

Published in: Cell & bioscience (2021)

The results of this study reveal SOX4-induced proteome changes in HCT-116 spheres and demonstrates that transcriptional activation of HDAC1 is the primary mechanism underlying SOX4 maintaining CSCs. This finding suggests that HDAC1 is a potential drug target for eradicating SOX4-driven human CSCs.

Keyphrases

transcription factor
stem cells
endothelial cells
histone deacetylase
mass spectrometry
epithelial mesenchymal transition
oxidative stress
risk assessment
dna methylation
induced pluripotent stem cells
climate change
adverse drug
stress induced