Pharmacokinetic Factors Associated With Early Meropenem Target Attainment in Pediatric Severe Sepsis.
Kelli PaiceSonya Tang GirdwoodTomoyuki MizunoKathryn PaviaNieko PuntPeter TangMin DongCalise CurryRhonda JonesAbigayle GibsonAlexander A VinksJennifer KaplanPublished in: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2024)
Eight of 29 pediatric patients with early severe sepsis did not meet the selected TA threshold within the first 24 hours of meropenem therapy. Higher clearance was associated with failure to meet targets. Identifying patients likely to have higher meropenem clearance could help with dosing regimens.