Aryliodonium Salt-Induced Regioselective Access to meta- Substituted Anilines by Arylation of Azoles.

A highly efficient aryliodonium salt-induced regioselective access to meta -substituted anilines by arylation of azoles has been developed under catalyst-free conditions. This efficient transformation provides a facile and scalable approach to a wide range of biologically active N -arylazoles with moderate to high yields. According to the control experiments, two plausible pathways, including a Michael pathway and a free radical coupling pathway, for the reaction were proposed.