Myeloid cell contributions to cardiovascular health and disease.
Matthias NahrendorfPublished in: Nature medicine (2018)
Recent advances in cell tracing and sequencing technologies have expanded our knowledge on leukocyte behavior. As a consequence, inflammatory cells, such as monocyte-derived macrophages, and their actions and products are increasingly being considered as potential drug targets for treatment of atherosclerosis, myocardial infarction and heart failure. Particularly promising developments are the identification of harmful arterial and cardiac macrophage subsets, the cells' altered, sometimes even clonal production in hematopoietic organs, and epigenetically entrained memories of myeloid progenitors and macrophages in the setting of cardiovascular disease. Given the roles of monocytes and macrophages in host defense, intricately understanding the involved cellular subsets, sources and functions is essential for the design of precision therapeutics that preserve protective innate immunity. Here I review how new clinical and preclinical data, often linking the cardiovascular, immune and other organ systems, propel conceptual advances to a point where cardiovascular immunotherapy appears within reach.
Keyphrases
- heart failure
- cardiovascular disease
- peripheral blood
- induced apoptosis
- dendritic cells
- single cell
- bone marrow
- cell cycle arrest
- cell therapy
- left ventricular
- type diabetes
- oxidative stress
- emergency department
- metabolic syndrome
- adipose tissue
- drinking water
- endoplasmic reticulum stress
- electronic health record
- endothelial cells
- drug induced
- acute heart failure
- human health
- smoking cessation