Haematopoietic stem cell transplantation in children with sickle cell disease: Still to do?
Christina PetersPublished in: British journal of haematology (2023)
Sickle cell disease affects the whole body through acute and chronic organ damage and results in significant physical and neurological constraints. The report by Cseh et al. demonstrates in a retrospective multinational study that allogeneic haematopoietic stem cell transplantation from HLA-identical siblings using a contemporary conditioning regimen is safe and effective in more than 96% of patients. Commentary on: Cseh et al. Myeloablative conditioning with busulfan or treosulfan is curative for children with sickle cell disease transplanted from a HLA-identical sibling donor: A study on behalf of the EBMT paediatric diseases and inborn errors working parties. Br J Haematol 2023 (Online ahead of print). doi: 10.1111/bjh.19015.
Keyphrases
- stem cell transplantation
- high dose
- sickle cell disease
- young adults
- end stage renal disease
- prognostic factors
- ejection fraction
- newly diagnosed
- emergency department
- physical activity
- intensive care unit
- mental health
- liver failure
- healthcare
- oxidative stress
- social media
- respiratory failure
- patient safety
- rectal cancer
- autism spectrum disorder
- patient reported
- brain injury
- blood brain barrier
- aortic dissection
- cerebral ischemia
- adverse drug