Novel mechanism of action for the mood stabilizer lithium.

Fahed A Abu-HijlehShreya PrasharHetshree JoshiRoohie SharmaBenicio Noronha Frey Ram K Mishra

Published in: Bipolar disorders (2020)

Taken together, these data suggest that lithium's therapeutic mechanism involves the maintenance of ER homeostasis via increased MANF gene expression mediated by the AP-1 transcription factor.

Keyphrases

transcription factor
gene expression
solid state
bipolar disorder
dna methylation
electronic health record
dna binding
big data
estrogen receptor
genome wide identification
machine learning
endoplasmic reticulum
artificial intelligence
data analysis
deep learning