Ethanol-Impaired Myogenic Differentiation is Associated With Decreased Myoblast Glycolytic Function.
Danielle Evé LevittNaveena ChalapatiMatthew J PrendergastLiz SimonPatricia E MolinaPublished in: Alcoholism, clinical and experimental research (2020)
During myoblast proliferation, EtOH decreased glycolytic metabolism and increased maximal OCR, suggesting that myoblast metabolic phenotype was dysregulated with EtOH. The EtOH-induced decrease in ECAR was associated with decreased differentiation. These findings suggest that EtOH-mediated shifts in metabolic phenotype may underlie impaired differentiation, which has important clinical implications for myogenesis in those affected by alcoholic myopathy.