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Ethanol-Impaired Myogenic Differentiation is Associated With Decreased Myoblast Glycolytic Function.

Danielle Evé LevittNaveena ChalapatiMatthew J PrendergastLiz SimonPatricia E Molina
Published in: Alcoholism, clinical and experimental research (2020)
During myoblast proliferation, EtOH decreased glycolytic metabolism and increased maximal OCR, suggesting that myoblast metabolic phenotype was dysregulated with EtOH. The EtOH-induced decrease in ECAR was associated with decreased differentiation. These findings suggest that EtOH-mediated shifts in metabolic phenotype may underlie impaired differentiation, which has important clinical implications for myogenesis in those affected by alcoholic myopathy.
Keyphrases
  • skeletal muscle
  • liver injury
  • drug induced
  • late onset
  • resistance training
  • early onset