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Severe muscle damage with myofiber necrosis and macrophage infiltrates characterize anti-Mi2 positive dermatomyositis.

Francesco GirolamoFrancesco GirolamoLorenzo CavagnaFranco FranceschiniMargherita GianniniAngela AmatiAnna LiaMarilina TampoiaDario D'AbbiccoLorenzo MaggiMicaela FrediGiovanni ZanframundoLiala MoschettiLaura ColadonatoFlorenzo Iannone
Published in: Rheumatology (Oxford, England) (2021)
Anti-Mi2+ patients represent a specific DM subset with high muscle damage. Histological hallmarks were a higher prevalence of myofiber necrosis, endomysial involvement and macrophage infiltrates at muscle biopsy.
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