Severe muscle damage with myofiber necrosis and macrophage infiltrates characterize anti-Mi2 positive dermatomyositis.
Francesco GirolamoFrancesco GirolamoLorenzo CavagnaFranco FranceschiniMargherita GianniniAngela AmatiAnna LiaMarilina TampoiaDario D'AbbiccoLorenzo MaggiMicaela FrediGiovanni ZanframundoLiala MoschettiLaura ColadonatoFlorenzo IannonePublished in: Rheumatology (Oxford, England) (2021)
Anti-Mi2+ patients represent a specific DM subset with high muscle damage. Histological hallmarks were a higher prevalence of myofiber necrosis, endomysial involvement and macrophage infiltrates at muscle biopsy.
Keyphrases
- skeletal muscle
- end stage renal disease
- oxidative stress
- adipose tissue
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- risk factors
- peritoneal dialysis
- interstitial lung disease
- systemic lupus erythematosus
- rheumatoid arthritis
- systemic sclerosis
- disease activity
- idiopathic pulmonary fibrosis