Characterizing the spatial distribution of dipeptides in rodent tissue using MALDI MS imaging with on-tissue derivatization.
Kening LiShuai GuoWeiwei TangBin LiPublished in: Chemical communications (Cambridge, England) (2021)
A highly efficient on-tissue derivatization method for the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) of dipeptides in tissues has been developed via a combination of a home-built laser-assisted chemical transfer (LACT) technique and hexafluoroisopropanol (HFIP).
Keyphrases
- mass spectrometry
- liquid chromatography
- high performance liquid chromatography
- high resolution
- gas chromatography
- highly efficient
- ms ms
- high resolution mass spectrometry
- capillary electrophoresis
- tandem mass spectrometry
- liquid chromatography tandem mass spectrometry
- simultaneous determination
- healthcare
- multiple sclerosis
- gene expression
- solid phase extraction
- high speed