M-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator.
Charissa WijnandsPieter LangerhorstSomayya NooriJenneke Keizer-GarritsenHans J C T WesselsJolein GloerichVincent BonifayHélène CaillonTheo M LuiderAlain J van GoolThomas DejoieMartijn M vanDuijnJoannes F M JacobsPublished in: Clinical chemistry and laboratory medicine (2023)
Compared to SIL peptides, SILuMAB-based MS-MRD improves the reproducibility, turn-around-times and cost-efficacy of MS-MRD without diminishing its sensitivity and specificity. Furthermore, SILuMAB can be used as a MS-MRD quality control tool to monitor sample preparation efficacy and assay performance.
Keyphrases
- mass spectrometry
- quality control
- multiple sclerosis
- ms ms
- liquid chromatography
- multiple myeloma
- end stage renal disease
- high resolution
- gas chromatography
- newly diagnosed
- ejection fraction
- capillary electrophoresis
- high performance liquid chromatography
- chronic kidney disease
- high throughput
- amino acid
- prognostic factors
- sensitive detection
- molecularly imprinted
- fluorescent probe