A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis.

Andrea ZelmerRachel TannerElena StylianouTimon DamelangSheldon MorrisAngelo IzzoAnn WilliamsSally SharpeIlaria PepponiBarry WalkerDavid A HokeyHelen McShaneMichael BrennanHelen Fletcher

Published in: BMC infectious diseases (2016)

We believe that the ex vivo mycobacterial growth inhibition assay could be a useful tool to help assess vaccine efficacy in future, alongside other established methods. It could also be a valuable tool for determination of underlying immune mechanisms.

Keyphrases

mycobacterium tuberculosis
high throughput
pulmonary tuberculosis
hiv aids
emergency department
mass spectrometry
adverse drug
single cell
human immunodeficiency virus
tandem mass spectrometry
antiretroviral therapy