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Veliparib with frontline chemotherapy and as maintenance in Japanese women with ovarian cancer: a subanalysis of efficacy, safety, and antiemetic use in the phase 3 VELIA trial.

Mika MizunoKimihiko ItoHidekatsu NakaiHidenori KatoShoji KamiuraKimio UshijimaShoji NagaoHirokuni TakanoMasao OkadomeMunetaka TakekumaHideki TokunagaSatoru NagaseDaisuke AokiRobert L ColemanYasuko NishimuraChristine K RatajczakHideyuki HashibaHao XiongNoriyuki KatsumataTakayuki EnomotoAikou Okamoto
Published in: International journal of clinical oncology (2022)
Median progression-free survival was numerically longer in Japanese patients in the veliparib-throughout versus control arm, consistent with results in the overall study population. Pharmacokinetics were comparable between Japanese and non-Japanese patients. Data for the subgroup of Japanese patients were not powered to show statistical significance but to guide further investigation.
Keyphrases
  • free survival
  • phase iii
  • clinical trial
  • study protocol
  • electronic health record
  • big data
  • phase ii
  • open label
  • data analysis