Systematic review with meta-analysis: placebo rates in induction and maintenance trials of Crohn's disease.
V JairathG ZouC E ParkerJ K MacDonaldM H MosliT AlAmeelM Al BeshirM AlMadiT Al-TaweelN S S AtkinsonS BiswasT P ChapmanP S DulaiM A GlaireD HoekmanO KheradA KoutsoumpasE MinasS RestelliniM A SamaanR KhannaB G LevesqueG D'HaensW J SandbornBrian G FeaganPublished in: Alimentary pharmacology & therapeutics (2017)
Placebo rates vary according to whether trials are designed for induction or maintenance and the factors influencing them differ for the endpoints of remission and response. These findings have important implications for clinical trial design in Crohn's disease.