Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation.

Sung-Eun LeeJi-Young LimTae Woo KimDa-Bin RyuSung Soo ParkYoung-Woo JeonJae-Ho YoonByung-Sik ChoKi-Seong EomYoo-Jin KimHee-Je KimSeok LeeSeok-Goo ChoDong-Wook KimJong Wook LeeChang-Ki Min

Published in: Journal for immunotherapy of cancer (2019)

Our data demonstrate that pre-ASCT M-MDSCs are correlated with poor clinical outcomes after ASCT through reduced cytotoxicity of melphalan. We propose that targeting CSF1R on these cells may improve the results of ASCT in MM.

Keyphrases

stem cell transplantation
induced apoptosis
high dose
cell cycle arrest
multiple myeloma
endoplasmic reticulum stress
oxidative stress
signaling pathway
low dose
cell death
stem cells
cell proliferation
drug delivery
machine learning