A natural product from Streptomyces targets PhoP and exerts antivirulence action against Salmonella enterica.

Roberto E BrunaAlejo CasalBárbara BercovichHugo GramajoEduardo RodríguezEleonora García Véscovi

Published in: The Journal of antimicrobial chemotherapy (2022)

Azomycin selectively inhibits the activity of the Salmonella virulence regulator PhoP, a new activity described for this nitroheterocyclic compound that can be repurposed to develop novel anti-Salmonella therapeutic approaches.

Keyphrases

escherichia coli
listeria monocytogenes
staphylococcus aureus
pseudomonas aeruginosa
transcription factor