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Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus-Positive Men by Validated Methylation Markers Associated With Progression to Cancer.

Ramon P van der ZeeOlivier RichelCarel J M van NoeselIuliana Ciocănea-TeodorescuAnnina P van SplunterTimo J Ter BraakMayura NathanTamzin CumingMichael SheaffAlexander KreuterChris J L M MeijerWim G V QuintHenry J C de VriesJan M PrinsRenske D M Steenbergen
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
We validated the accuracy of 5 methylation markers for the detection of anal (pre-) cancer. High methylation levels in HGAIN were associated with progression to cancer. These markers provide a promising tool to identify HGAIN in need of treatment, preventing overtreatment of HGAIN with a low cancer progression risk.
Keyphrases
  • papillary thyroid
  • human immunodeficiency virus
  • squamous cell
  • high grade
  • dna methylation
  • genome wide
  • squamous cell carcinoma
  • lymph node metastasis
  • childhood cancer
  • antiretroviral therapy
  • hiv aids
  • young adults