Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus-Positive Men by Validated Methylation Markers Associated With Progression to Cancer.
Ramon P van der ZeeOlivier RichelCarel J M van NoeselIuliana Ciocănea-TeodorescuAnnina P van SplunterTimo J Ter BraakMayura NathanTamzin CumingMichael SheaffAlexander KreuterChris J L M MeijerWim G V QuintHenry J C de VriesJan M PrinsRenske D M SteenbergenPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
We validated the accuracy of 5 methylation markers for the detection of anal (pre-) cancer. High methylation levels in HGAIN were associated with progression to cancer. These markers provide a promising tool to identify HGAIN in need of treatment, preventing overtreatment of HGAIN with a low cancer progression risk.