Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State.

Kenneth L Pitter Olivera Grbovic-Huezo Simon Joost Anupriya Singhal Melissa Blum Katherine Wu Matilda Holm Alexander Ferrena Arjun Bhutkar Anna Hudson Nicolas Lecomte Elisa De Stanchina Ronan Chaligné Christine A Iacobuzio-Donahue Dana Pe'er Tuomas Tammela

Published in: Cancer research (2022)

This work provides important insights into how different model systems of pancreatic ductal adenocarcinoma mold the phenotypic space of cancer cells, highlighting the power of in vivo models.

Keyphrases

single cell
genome wide
cell therapy
transcription factor
stem cells
mesenchymal stem cells
bone marrow