Dyslexia-Related Hearing Loss Occurs Mainly through the Abnormal Spontaneous Electrical Activity of Spiral Ganglion Neurons.
Guodong HongXiaolong FuXin ChenLiyan ZhangXuan HanShuqin DingZiyi LiuXiuli BiWen LiMiao ChangRuifeng QiaoSiwei GuoHailong TuRen-Jie ChaiPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Dyslexia is a reading and spelling disorder due to neurodevelopmental abnormalities and is occasionally found to be accompanied by hearing loss, but the reason for the associated deafness remains unclear. This study finds that knockout of the dyslexia susceptibility 1 candidate 1 gene (Dyx1c1 -/- ) in mice, the best gene for studying dyslexia, causes severe hearing loss, and thus it is a good model for studying the mechanism of dyslexia-related hearing loss (DRHL). This work finds that the Dyx1c1 gene is highly expressed in the mouse cochlea and that the spontaneous electrical activity of inner hair cells and type I spiral ganglion neurons is altered in the cochleae of Dyx1c1 -/- mice. In addition, primary ciliary dyskinesia-related phenotypes such as situs inversus and disrupted ciliary structure are seen in Dyx1c1 -/- mice. In conclusion, this study gives new insights into the mechanism of DRHL in detail and suggests that Dyx1c1 may serve as a potential target for the clinical diagnosis of DRHL.
Keyphrases
- hearing loss
- high fat diet induced
- genome wide
- copy number
- induced apoptosis
- spinal cord
- genome wide identification
- resting state
- dna methylation
- cell proliferation
- oxidative stress
- gene expression
- signaling pathway
- cell death
- functional connectivity
- insulin resistance
- working memory
- optical coherence tomography
- optic nerve
- type diabetes