Autophagy Inhibition as a Potential Therapeutic Strategy for Breast Cancer with Mitochondrial Translation Defect Caused by CBFB-Deficiency.

Navdeep MalikHualong YanYoung-Im KimGamze AyazShasha WangPayel MondalJi LuoJing Huang

Published in: Autophagy (2023)

AMPK, AMP-activated protein kinase; BioID, biotinylation identification; CBFB, core-binding factor subunit beta; HCQ, hydroxychloroquine; HNRNPK, heterogeneous nuclear ribonucleoprotein K; PDX, patient-derived xenograft; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; TUFM, Tu translation elongation factor, mitochondrial; ETC, electron transport chain.

Keyphrases

protein kinase
oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
skeletal muscle
dna binding