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An overview on the relationship between residential radon and lung cancer: what we know and future research.

Alberto Ruano-RaviñaLucía Martín-GisbertKarl T KelseyMónica Pérez-RíosCristina Candal-PedreiraJulia ReyLeonor Varela-Lema
Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
We aim to provide an overview of the research available on indoor radon and lung cancer, with a special focus on Spanish investigations. Early studies on underground miners established the link between radon and lung cancer, which was later confirmed for the general population by residential case-control studies. Spain contributed with extensive evidence, including 5 multicentric, hospital-based, case-control studies in the last 30 years, exploring diverse aspects, such as radon's effect on never-smokers, molecular pathways linking radon exposure to lung cancer risk, survival rates, mortality burden, and occupational exposure. There is a well-established causal association between radon with lung cancer. Despite pioneering research performed in our country by the Galician Radon Laboratory, particularly on driver genes, the evidence on the potential molecular pathways which makes radon a carcinogen is sparse. Also, relevant questions on the potential association of radon exposure with the induction of other diseases are still pending.
Keyphrases
  • case control
  • air pollution
  • risk factors
  • risk assessment
  • dna methylation
  • drinking water
  • health risk
  • bioinformatics analysis