Peak Force Infrared-Kelvin Probe Force Microscopy.
Devon S JakobHaomin WangGuanghong ZengDaniel Erik OtzenYong YanXiaoji G XuPublished in: Angewandte Chemie (International ed. in English) (2020)
Correlative scanning probe microscopy of chemical identity, surface potential, and mechanical properties provide insight into the structure-function relationships of nanomaterials. However, simultaneous measurement with comparable and high resolution is a challenge. We seamlessly integrated nanoscale photothermal infrared imaging with Coulomb force detection to form peak force infrared-Kelvin probe force microscopy (PFIR-KPFM), which enables simultaneous nanomapping of infrared absorption, surface potential, and mechanical properties with approximately 10 nm spatial resolution in a single-pass scan. MAPbBr3 perovskite crystals of different degradation pathways were studied in situ. Nanoscale charge accumulations were observed in MAPbBr3 near the boundary to PbBr2 . PFIR-KPFM also revealed correlations between residual charges and secondary conformation in amyloid fibrils. PFIR-KPFM is applicable to other heterogeneous materials at the nanoscale for correlative multimodal characterizations.
Keyphrases
- single molecule
- high resolution
- atomic force microscopy
- living cells
- high speed
- photodynamic therapy
- quantum dots
- computed tomography
- mass spectrometry
- magnetic resonance imaging
- drug delivery
- cancer therapy
- room temperature
- molecular dynamics simulations
- risk assessment
- chronic pain
- pain management
- fluorescence imaging
- fluorescent probe
- single cell