Identification of a human blood biomarker of pharmacological 11β-hydroxysteroid dehydrogenase 1 inhibition.
Cristina GómezZerin AlimajstorovicNantia OthonosDenise V WinterSarah WhiteGareth G LaveryJeremy W TomlinsonAlexandra J SinclairAlex OdermattPublished in: British journal of pharmacology (2023)
11β-HSD1 inhibition does not cause major alterations in bile acid homeostasis. The GUDCA/G7oxoLCA ratio represents the first blood biomarker of pharmacological 11β-HSD1 inhibition and may replace or complement the urinary (5αTHF+THF)/THE ratio biomarker.