Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates.

Marika BogdaniCate SpeakeMathew J DufortPamela Y JohnsonMegan J LarmoreAnthony J DayThomas N WightÅke LernmarkCarla J Greenbaum

Published in: Diabetologia (2020)

This study indicates that HA deposition in islets occurs early in type 1 diabetes and prior to insulitis, and points to a potential role of HA in triggering islet immune-cell infiltration and the promotion of insulitis.

Keyphrases

type diabetes
cardiovascular disease
risk assessment
human health
skeletal muscle
climate change