Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy.
Jumin HuangDi LiuYuwei WangLiang LiuJian LiJing YuanZhihong JiangZebo JiangWl Wendy HsiaoHaizhou LiuImran KhanYing XieJianlin WuYajia XieYizhong ZhangYu FuJunyi LiaoWenjun WangHuanling LaiAxi ShiJun CaiLianxiang LuoRunze LiXiaojun YaoXingxing FanQibiao WuZhongqiu LiuPeiyu YanJingguang LuMingrong YangLin WangYabing CaoHong WeiElaine Lai-Han LeungPublished in: Gut (2021)
Our results demonstrate that GPs combined with αPD-1 mAb may be a new strategy to sensitise non-small cell lung cancer patients to anti-PD-1 immunotherapy. The gut microbiota can be used as a novel biomarker to predict the response to anti-PD-1 immunotherapy.