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Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions.

Yi TangLin LiuPei WangDonglei ChenZiqiang WuChunbo Tang
Published in: Cell proliferation (2017)
Our results revealed that POSTN might promote the migration and osteogenic differentiation potential of PDLSCs via the JNK pathway, providing insight into the mechanism underlying MSC biology under inflammatory conditions and identifying a potential target for improving periodontal tissue regeneration.
Keyphrases
  • mesenchymal stem cells
  • signaling pathway
  • oxidative stress
  • endothelial cells
  • cell death
  • bone marrow
  • umbilical cord
  • stem cells
  • induced apoptosis
  • human health
  • single cell
  • cell therapy