Assessment of muscle function using hybrid PET/MRI: comparison of 18F-FDG PET and T2-weighted MRI for quantifying muscle activation in human subjects.
Bryan Thomas HaddockSøren HolmJákup M PoulsenLotte H EnevoldsenHenrik B W LarssonAndreas KjærCharlotte SuettaPublished in: European journal of nuclear medicine and molecular imaging (2016)
This is the first assessment of skeletal muscle activation using hybrid PET/MRI and the first study to demonstrate a high correlation between 18F-FDG uptake and changes in muscle T 2 with physical exercise. Accordingly, it seems that changes in muscle T 2 may be used as a surrogate marker for glucose uptake and lead to an improved insight into the metabolic changes that occur with muscle activation. Such knowledge may lead to improved treatment strategies in patients with neuromuscular pathologies such as stroke, spinal cord injuries and muscular dystrophies.
Keyphrases
- skeletal muscle
- pet ct
- positron emission tomography
- contrast enhanced
- pet imaging
- computed tomography
- spinal cord
- magnetic resonance imaging
- insulin resistance
- endothelial cells
- spinal cord injury
- atrial fibrillation
- magnetic resonance
- type diabetes
- adipose tissue
- neuropathic pain
- blood glucose
- blood pressure
- network analysis
- induced pluripotent stem cells
- brain injury