The Potential In Vitro Inhibitory Effects of Neurokinin-1 Receptor (NK-1R) Antagonist, Aprepitant, in Osteosarcoma Cell Migration and Metastasis.

Mohammed Ali Alsaeed Safieh Ebrahimi Abbas Alalikhan Seyedeh Fatemeh Hashemi Seyed Isaac Hashemy

Published in: BioMed research international (2022)

Collectively, our observations indicate that aprepitant modulates the metastatic behavior of human osteosarcoma cells, which may be applied to an effective therapeutic approach for patients with metastatic osteosarcoma.

Keyphrases

cell migration
induced apoptosis
endothelial cells
small cell lung cancer
squamous cell carcinoma
cell cycle arrest
induced pluripotent stem cells
signaling pathway
cell proliferation
human health