Development of clinical decision support alerts for pharmacogenomic incidental findings from exome sequencing.

Adam A NishimuraBrian H ShirtsMichael O DorschnerLaura M AmendolaJoe W SmithDavid L VeenstraPeter Tarczy-Hornoch

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2015)

Reflections on the process reveal that while incidental findings can be used to generate decision support alerts, substantial resources are required to ensure that each alert is consistent with rapidly evolving pharmacogenomic literature and is customized to fit in the clinical workflow unique to each incidental finding.

Keyphrases

clinical decision support
electronic health record
single cell
systematic review
genome wide
gene expression
copy number
dna methylation