Suppression of TBCK enhances TRAIL-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma Caki-1 cells.

Cho-Young ParkJi-Hoon JangIn-Hwan SongJoo-Young KimKyung-Oh DohTae-Jin Lee

Published in: Genes & genomics (2023)

These data suggest that TBCK could potentially have a crucial function in influencing the effects of anti-cancer drugs including TRAIL by modulating the signaling pathway involving Akt and PDK1 in human renal cancer cells.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
endothelial cells
epithelial mesenchymal transition
cell cycle arrest
cell proliferation
electronic health record
big data
endoplasmic reticulum stress
machine learning
cell death
artificial intelligence