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Phenotypic characterization of nonautoimmune diabetes in adult Ugandans with low body mass index.

Davis KibirigeIsaac SekitolekoWilliam LumuNihal ThomasMeredith HawkinsAngus G JonesAndrew T HattersleyLiam SmeethMoffat J Nyirenda
Published in: Therapeutic advances in endocrinology and metabolism (2024)
This study demonstrates that nonautoimmune diabetes occurs in underweight individuals in sub-Saharan Africa and is characterized by the absence of visceral adiposity, reduced late-phase insulin secretion, and greater insulin deficiency. These findings necessitate further studies to inform how the prevention, identification, and management of diabetes in such individuals can be individualized.
Keyphrases
  • type diabetes
  • glycemic control
  • cardiovascular disease
  • body mass index
  • insulin resistance
  • weight gain
  • physical activity
  • young adults
  • adipose tissue
  • replacement therapy
  • skeletal muscle