Phenotypic characterization of nonautoimmune diabetes in adult Ugandans with low body mass index.
Davis KibirigeIsaac SekitolekoWilliam LumuNihal ThomasMeredith HawkinsAngus G JonesAndrew T HattersleyLiam SmeethMoffat J NyirendaPublished in: Therapeutic advances in endocrinology and metabolism (2024)
This study demonstrates that nonautoimmune diabetes occurs in underweight individuals in sub-Saharan Africa and is characterized by the absence of visceral adiposity, reduced late-phase insulin secretion, and greater insulin deficiency. These findings necessitate further studies to inform how the prevention, identification, and management of diabetes in such individuals can be individualized.