Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa.

Claudio D'AddarioElizabeta ZaplaticElisa GiuntiMariangela Pucci Maria Vittoria Micioni Di Bonaventura Maria Scherma Enrico DaineseMauro MaccarroneIda A K Nilsson Carlo Cifani Paola Fadda

Published in: The International journal of eating disorders (2020)

Our findings support a possible role for Cnr1 in the ABA animal model of AN. In particular, its regulation in the nucleus accumbens appears to be triggered by environmental cues due to the consistent epigenetic modulation of the promoter. These data warrant further studies on Cnr1 regulation as a possible target for treatment of AN.

Keyphrases

anorexia nervosa
dna methylation
transcription factor
gene expression
electronic health record
arabidopsis thaliana
human health
machine learning
binding protein
smoking cessation