Multi-species transcriptome meta-analysis of the response to retinoic acid in vertebrates and comparative analysis of the effects of retinol and retinoic acid on gene expression in LMH cells.
Clemens Falker-GieskeAndrea MottSören FranzenburgJens TetensPublished in: BMC genomics (2021)
We propose that these RARCCs stand on top of a common regulatory RA hierarchy among vertebrates. Based on the protein sets included in these clusters we were able to identify an RA-response cluster, a control center type cluster, and a cluster that directs cell proliferation. Concerning the comparison of the cellular response to RA and RO we conclude that ncRNAs play an underestimated role in retinoid-mediated gene regulation.
Keyphrases
- gene expression
- rheumatoid arthritis
- cell proliferation
- systematic review
- disease activity
- induced apoptosis
- ankylosing spondylitis
- dna methylation
- meta analyses
- cell cycle arrest
- genome wide
- single cell
- rna seq
- cell cycle
- amino acid
- signaling pathway
- pi k akt
- protein protein
- endoplasmic reticulum stress
- binding protein
- systemic sclerosis
- case control